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[ ABSTRACT] AIM:To investigate the combined effect of octreotide and Dachaihu decoction on the treatment of severe acute pancreatitis (SAP).METHODS:Wistar rats (n=50) were randomly divided into sham group, SAP group, octreotide group, Dachaihu decoction group and combination group.The quantity of ascites was measured.The levels of amylase, alanine aminotransferase and creatinine in the serum were examined.The morphological changes of the pancreatic tissues were observed by HE staining.The activation of NF-κB and IκBαexpression were determined by Western blot.The mRNA expression with ICAM-1 and IL-1 was detected by qPCR.RESULTS: Combined treatment with octreotide and Dachaihu decoction effectively reduced the quantity of ascites and the levels of amylase, alanine aminotransferase and creat-inine in the serum in SAP rats.Moreover, combined treatment significantly inhibited SAP-induced activation of NF-κB and decrease in IκBαprotein expression, accompanied by a decrease in ICAM-1 and IL-1 mRNA expression.CONCLU-SION:Combination of octreotide with Dachaihu decoction effectively attenuates SAP by inhibiting NF-κB signaling pathway and ICAM-1 and IL-1 expression.
ABSTRACT
Objective To explore the therapeutic effect of Fuzbeng-Liqi mixture on hepatitis resulted from anti-tuberculosis drugs.Methods 100 inpatients of hepatitis resulted from anti-tuberculosis drugs during January 2005 to December 2007 were randomly sorted out into a treatment group and a control group.The treatment group was treated with Fuzbeng-Liqi mixture,and the control group was treated with routine drugs.The effect was analyzed by 2/2 test.Results The therapeutic effect of the treatment group markedly excelled than the control group in terms of symptoms improvement such as nausea or vomit,tiredness,icterus,bepatalgia,or augment of liver.Conclusion Fuzbeng-Liqi mixture was not only able to ameliorate the clinical manifestations of drug-induced hepatitis,but also improve hepatic function.